In recent genome sequencing studies, a de novo mutation in ZNF292 has been linked to autism spectrum disorder (ASD). ZNF292, codes for zinc finger protein 292, and was recently discovered by Mirzaa et al. (2018). Mirzaa et al. found that ZNF292 is present in the brain during development, and that ZNF292 plays a role in transcription as well as in the regulation of voluntary movements. Few studies have been conducted to find out more about the role of ZNF292 in terms of risk of ASD. In this study, it is speculated that the de novo mutations or variants in ZNF292 are pathogenic for a spectrum of neurodevelopmental disorders such as ASD and intellectual disability (ID). Our findings suggest that there is no significant difference in the levels of ZNF292 between control mice and mice used as ASD models when ZNF292 is not mutated. We believe that further research is needed in order to better understand the impact ZNF292 mutations have on protein expression in ASD model organisms.
